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Duloxetine Hydrochloride

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  • Product Information
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Delayed release capsules for the treatment of major depressive disorder; generalized Anxiety Disorder; Diabetic Peripheral Neuropathy; and Chronic Musculoskeletal Pain. Can help relieve nerve pain in patients with diabetes, chronic back pain, arthritis, or fibromyalgia.

Duloxetine delayed-release capsules, USP (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS∙HCl, which corresponds to a molecular weight of 333.88.

  • Indications and Use
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Duloxetine delayed-release capsules are a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for:

  1. Major Depressive Disorder (MDD)
  2. Generalized Anxiety Disorder (GAD)
  3. Diabetic Peripheral Neuropathic Pain (DPNP)
  4. Chronic Musculoskeletal Pain
  • Dosage and Administration
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Take Duloxetine hydrochloride delayed release capsules once daily, with or without food. Swallow the capsule whole, do not crush or chew. Take a missed dose as soon as it is remembered. Do not take two doses of at the same time. Dosage may be specific to disorder being treated.

  • Information for the Patient
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Read information on Medication Guide to be informed about the benefits and risks associated with treatment with Duloxetine delayed-release capsules and counsel them in its appropriate use. A patient Medication Guide is available for Duloxetine delayed-release capsules.Alert your prescriber if Suicidal Thoughts or Behavior issues occur while taking Duloxetine delayed-release capsules.While patients may notice improvement with Duloxetine delayed-release capsules therapy in 1 to 4 weeks, advise patients to continue therapy as directed.

  • Warnings
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Read Drug Label Information for complete list of warnings and precautions. Which may include Suicidal Thoughts and Behaviors; Hepatotoxicity, Orthostatic Hypotension, Falls and Syncope; Serotonin Syndrome; Abnormal Bleeding; Severe Skin Reactions; Discontinuation of Treatment; Activation of Mania/Hypomania; Angle-Closure Glaucoma; Seizures; Effect on Blood Pressure; Hyponatremia; Urinary Hesitation and Retention. Consult your healthcare provider immediately if you experience any adverse reactions.